The American Dream - 1179 Words

Set during the gruelling Great Depression of the 1930’s, John Steinbeck’s touching novella Of Mice and Men focuses on the working class of America and two men, George Milton and Lennie Small, as they work on a ranch in hopes of owning their own land. Set in the dusty town of Soledad, California, Steinbeck’s classic characters offer a parable about what it means to be human. George and Lennies ambition of owning their own ranch, and the obstacles that stand in the way of that ambition, reveal the impossibility of the American Dream, while the loneliness and isolation of the members of the ranch offer a true insight into the nature of human existence, especially when the weaknesses of the characters cause them to destroy those more†¦show more content†¦An have rabbits. Go on, George! Tell about what were gonna have in the garden and about the rabbits in the cages and about the rain in the winter and the stove, tell about that George.† The jovial reac tion of both George and Lennie primes readers to recognise that it’s never going to be a reality, particularly from their unrealistic approach to the dream. Through dialogue and imagery, the readers are positioned to have a optimistic and hopeful attitude towards the character’s hopeless yet passionate dreams. Although their fates are sealed, their dreams are used as an outlet from reality, especially from a strenuous time like the Great Depression. Steinbeck consistently educates the readers throughout Of Mice and Men about the nature of human existence. Nearly all of the characters admit to having a sense of loneliness and isolation on the ranch and each desires the shoulder of a friend, and will even settle for a stranger out of their loneliness. Crooks tells Lennie life is considered pointless if there is no companion to turn to in times of need and Curley’s wife confesses consistently to the ranchmen that she is unhappily married. However, despite at their weakest, they destroy those more vulnerable. An example is the cruel tendency where Crooks crushes Lennie’s dream of the farm and criticises his dependence on George. Crooks, aware of Lennie’s mental disability, tortures him about his fears on page 71. â€Å"He won’t do it.† LennieShow MoreRelatedImmigrants And The American Dream1362 Words   |  6 PagesImmigrants and the American Dream In the article â€Å"The American Dream†, by James Truslow Adams in The Sundance Reader book, he stated that the American dream is that dream of a land in which life should be better and richer and fuller for everyone, with opportunity for each according to ability or achievement. It is a difficult dream for the European upper classes to interpret adequately, and too many of us ourselves have grown weary and mistrustful of it. It is not a dream of motor cars and highRead MoreThe American Dream By Kimberly Amadeo1637 Words   |  7 PagesNowadays, a large number of people migrate to the United States to work and achieve the American Dream. According to the Article â€Å"What is the American Dream?† by Kimberly Amadeo, â€Å"The American Dream was first publicly defined in 1931 by James Truslow Adams in Epic of America. Adam’s often-repeated quote is, ‘The American Dream is that dream of land in which life should be better and richer and fuller for everyon e, with opportunity for each according to ability or achievement.’† There are many peopleRead MoreAnalysis Of The Movie The American Dream 754 Words   |  4 Pages Nyreel Powell Ms. Jones American Literature 1 June 2015 The American dream in A Raisin in the Sun Have you ever had a dream and it didn’t come how you wanted it to be? Have you ever had accomplishments that you wanted to achieve but people were getting in the way of them? The four main characters in this book all have good dreams but there are people in the way of getting to those dreams or their dream is too high to accomplish. A Raisin in the Sun a play written by Lorraine Hansberry, andRead MoreSister Carrie and the American Dream1618 Words   |  7 PagesThe American Dream is surely based on the concept of â€Å"Life, Liberty and the Pursuit of Happiness† but it is above all, a matter of ambition. James Truslow Adams, an American writer and historian, in 1931 states: life should be better and richer and fuller for everyone, with opportunity for each according to ability or achievement†, which not only points towards a better standard of living for Americans but also denounces a degree of greed in the US society. Ambition not only â€Å"killed the catâ₠¬  butRead MoreGrapes Of Wrath And The American Dream1644 Words   |  7 PagesThe idea of the American Dream is ever changing depending on the person and the time of life that person is in. Although the main ideas of the American Dream remain the same to be educated, economically sound, healthy, to have a family, and equal rights. Many great films and works of literature were created to show case all the different ideas people have for their American Dream. The film â€Å"Grapes of Wrath† directed by John Ford and the poem â€Å"I Will Fight No More Forever† by Chief Joseph, both depictRead More Destruction of the American Dream Essay2145 Words   |  9 PagesDestruction of the American Dream I’ve talked about it in the past, the destruction of the American Dream. Always, there have been papers, writings, and thoughts that quantify a particular section of its ultimate demise, be it due to money, education, or sexuality. Maybe the destruction cannot be viewed as a singular event or cause. Perhaps instead it must be examined as a whole process, the decay and ultimate elimination of a dream. Self destruction, if you will†¦ Mr. Self Destruct Read MoreSuccess As One Of The American Dream1137 Words   |  5 PagesApril 2015 Success as One of The American Dream When we hear the word â€Å"success†, we often think of wealth and money. To some people, the embodiment of being success is earning a lot of money. In fact, the concept of success is primarily based on how much money a person earns. However, each person views the definition of success differently. One way to define success is something that has more to do with flash than it does with substance. John Wooden, an American basketball player and coach viewRead MoreJim Cullen And The American Dream2081 Words   |  9 Pages The American Dream, as defined by Cullen, is starting your goal off with a little and ending with more; it s like a business, you invest in it in order to gain more money. Usually, people will define the American Dream as being able to achieve your goal because everyone is offered opportunities. Cullen does acknowledge that people are born with different opportunities, so he talks about the good life. The good life describes different factors that determine your opportunities. Throughout the otherRead MoreFactors Influencing The American Dream1834 Words   |  8 Pagesindividual to succumb or to not succumb to the seductions of crime. These three factors are brilliantly portrayed in the television show, Breaking Bad and the novel, The Stick Up Kids. The American Dream is what many American citizens strive for. However, not all of those citizens are able to achieve the American Dream through a legal pathway. The reason an indivudal may not being able to do so is because of his or her background factors. It is important to note that background factors are a fractionRead MoreShark Tank And The American Dream1755 Words   |  8 PagesShark Tank and The American Dream The TV show Shark tank embodies everything the American dream represents. The show obtains successful Entrepreneurs ready to invest their own money into other Americans wanting to be just like them, reaching the American dream and become a successful entrepreneur. The show presents entrepreneurs working towards the goal of creating a business to not only gain wealth but also change the way we live today. The show is to keep the American dream alive and well while

Sparate Peace Free Essays

In the novel Separate Peace, John Knowles uses both positive and negative scenes throughout the novel. John Knowles does this to show how the setting can affect the characters and the events that are being taken throughout the novel. Knowles introduces right away that there are two big scenes, the summer session and the winter session, both playing big roles in the story’s plot and theme. We will write a custom essay sample on Sparate Peace or any similar topic only for you Order Now The summer session would represent peace and the winter session would represent the distress brought on by World War II, the shift between them clearly confirms that Knowles intended to show how completely and abruptly the war overtook the peace at the summer session. Knowles uses the summer session setting to symbolize peace. Knowles uses the positive setting described in this quote to reveal the importance of the setting: â€Å"They (elms) too seemed permanent and never changing, an untouched, unreachable world high in space, like the ornamental towers and spires of a great church, too high to be enjoyed, too high for anything, great and remote and never useful†. Knowles describes the setting like this to create a peaceful image representing the summer session as a time of peace. This also brings a vividly peaceful image to mind further connecting the concepts of summer and peace together which is later conquered by the war elements of winter. Knowles uses the winter session setting to symbolize the distress of the war. Knowles uses this as the negative setting in the novel. In this quote, he describes the importance of the setting: â€Å"Not long afterward, early even for New Hampshire, snow came†¦They gathered there, thicker by the minute, like noiseless invaders conquering because they took possession so gently. I watched them whirl by my window-don’t take this seriously, the playful way they fell seemed to imply, this little show, this harmless trick†. Knowles uses words such as invaders and conquering to connect this image to the war zone. This shows Knowles’ elements of the war and how it overtook the peace present and the Devon School. Knowles also writes that these elements of winter conquered the life of nature which had previously been a symbol of summer. This strengthens his intent of highlighting how the war element of winter took over the peace of summer. The change between the previous positive setting of summer and the negative setting of winter represents the effect the war had on the peace at the Devon School. The time that Finny and Gene spend at the beach represents the peak of the summer. However, overnight it is followed by this description of the ocean: â€Å"The Ocean looked dead too, dead waves hissing mordantly along the beach, which was gray and dead looking itself†. Here Knowles uses words such as â€Å"dead†, â€Å"hissing†, and â€Å"grey†, which have a negative meaning, to create a powerful negative setting scene in the novel. This causes an unexpected contrast between negative and positive settings. This piercing contrast between the beach and a â€Å"dead† ocean, which meets the beach at the shore with the hissing of dead waves, foreshadows the sharp contrast between the peace of summer and the distress of winter that meets the summer of Finny’s fall. This event is the symbolic fall of peace to the distress of war. Knowles cements this fact with stating the setting of the situation just before his fall, claiming that â€Å"From behind us the last long rays of light played across the campus, accenting every slight undulation of the land, emphasizing the separateness of each bush†. The last long rays of light show the end of summer because the end of the long days marks the beginning of autumn season due to daylight savings time. Since the summer session represents peace and the winter session represents distress, this shows that Finny’s fall from the tree marks the fall of peace to distress. John Knowles use of setting scenes strengthens his idea in the novel of the peace at Devon school being overtaken by the elements of World War II. This is done by the addition of positive settings of summer which represent the peace at the school; and winter, which represents the invasion of the war and the piercing contrast between these two types of settings at certain scenes throughout the novel. How to cite Sparate Peace, Essay examples

Christopher Columbus (1451

Christopher Columbus (1451-1506) Essay Christopher Columbus was born in 1451 Calvi (Corsica), northwest of the island, 200km from Ajaccio. He was the oldest of five children. As a child, he helped his father as a weaver. He always liked the sea. Genoa was an important seaport. There is no doubt that as a child he caught rides on ships. He had little schooling but was a genius with the sea. His plan was not to prove that the world was flat, but it was to find a shortcut to the Spice Islands. He wanted to establish a city there for trade, seaports, and much more. When he grew into a man he was interested in sailing to Asia by going west. First he went to the king of Italy and presented his idea before him. Italy wasnt looking for a way to Asia; they were still receiving riches from their old trade routes. His three ships were the Santa Maria, the Nina, and the Pinta. Important Facts About Christopher Columbus * In 1492, he left Spain for his first voyage. He landed in San Salvador at Cap- Haitien and returned home to Palos, Spain, in 1493. *In 1493, he left Spain for his second voyage. He landed on Marie-Galante, then went again in Cap-Haitien, St. Anns Bay, and returned to Cadiz, Spain, in 1496. *In 1498, he left Spain for his third voyage. He landed in Santo Domingo, and returned home again to Cadiz, Spain in 1500. *In 1502, he left Spain for his fourth and final voyage. He landed on the Bay Islands off of Central America, Portobelo, and then returned home to Sanlucar, Spain, for the final time. *He later died in 1506. Man and Myth After five centuries, Columbus remains a mysterious and controversial figure who has been variously described as one of the greatest mariners in history, a visionary genius, a mystic, a national hero, a failed administrator, a naive entrepreneur, and a ruthless and greedy imperialist. Columbuss enterprise to find a westward route to Asia grew out of the practical experience of a long and varied maritime career, as well as out of his considerable reading in geographical and theological literature. He settled for a time in Portugal, where he tried unsuccessfully to enlist support for his project, before moving to Spain. After many difficulties, through a combination of good luck and persuasiveness, he gained the support of the Catholic monarchs, Isabel and Fernando. The widely published report of his voyage of 1492 made Columbus famous throughout Europe and secured for him the title of Admiral of the Ocean Sea and further royal patronage. Columbus, who never abandoned the belief that he had reached Asia, led three more expeditions to the Caribbean. But intrigue and his own administrative failings brought disappointment and political obscurity to his final years. .

Virtue Ethics free essay sample

Albanian’s have a tradition where if a man commits a murder the victim’s family can kill any one of his male relatives in reprisal. If a boy is born into a family where his brother/son was a murderer he has to go into hiding; leaving proper education adequate health care. Can we argue that Albanians are ‘morally wrong to have structured their society in this way?’ and ‘are their values are inferior to our own? ’ Can we argue whether or not, scientifically, one life is better than another? Argues that human well-being always depends of events in the world and states of the human mind – must be scientific truths behind it Mistaking no answers in practice for no answers in principle is a great source of confusion – e. g. 21 US states still allow corporal punishment in schools (majority in the south) Morality should be considered an undeveloped branch of science The scientific communities reluctance to take stand on moral issues makes science appear divorced from the most important questions of human life We must acknowledge that the intellectual terrain actually exists to achieve a science of human flourishing Hypothetical space called the ‘moral landscape’ – peaks corresponded to heights of potential well-being valleys represent the deepest possible suffering. We will write a custom essay sample on Virtue Ethics or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Many people think a universal conception of morality requires us finding moral principles that admit no exception if it is truly wrong to lie, it must always be wrong to lie. If one can find a single exception, any notion of moral truth must be abandoned. Chess the queen (sometimes a good thing to lose your queen) Human knowledge and human values can no longer be kept apart David Hume – ‘no description of the way the world is (facts) can tell us how we ought to behave (morality). G. E. Moore – any attempt to locate moral truths in the natural world was to commit a ‘naturalistic fallacy’

buy custom Anorexia Nervosa essay

buy custom Anorexia Nervosa essay Eating Disorder An eating disorder is a type of illness that is characterized by eating behaviors that deviate from the normal eating habits and is usually a response to a psychological or emotional need of self criticism and negative thoughts of oneself. In trying to satisfy these needs, a person develops certain rituals about food, weight, and body shape leading to indulgence in over eating or refusing to eat by ignoring normal body signals for example not eating even when hungry or consuming excess food even when the person is satisfied. Abnormal eating patterns which include anorexia nervosa, bulimia nervosa and binge eating are the three major types of disorders. Anorexia Nervosa Anorexia nervosa is a type of eating isorder where a person has an extreme weight phobia and has an obsession to remain being thin always. Due to this fear, people with anorexia strive to keep their body weight to the low by self starvation or refusing to eat, self-induced vomiting, fasting or by doing excessive exercises and abuse of diet aids. Although there are few cases affecting men, this disorder is usually common with young women starting usually at the adolescence stage or early childhood. Causes of anorexia are not clearly known although certain mixed causes involving psychological factors, social factors, age, stress levels, family and genetic influence are believed to take role. Some of the symptoms of anorexia include intense weight phobia, desire to lose weight despite being thin, constant awareness of their weight, excessive exercises and keeping strict routines of them, certain food choices like salads and for women, lack menstrual periods. Some of the effects of anorexia may include malnutrition, emaciation, hair loss, low blood pressure, organ failures, bone thinning, brain damage, infertility and even death. Treatment of anorexia has not been uniquely identified although many of the forms of treatment include medical supervision, psychotherapy and nutrition therapy. An attempt to restore weight to a healthy and normal size is the key component to any form of treatment but some extreme cases of weight loss may require hospitalization. The use of some medicines such as antidepressants, mood stabilizers and antipsychotics has also been thought to treat anorexia. A better form of treatment involving a combination of supervised medical attention and supportive psychotherapy is also currently being proposed and is thought to be effective than therapy alone. Buy custom Anorexia Nervosa essay

6 common traits of horrible bosses

6 common traits of horrible bosses While in a perfect world your boss would be a magical combination of friend and mentor, you’re very lucky if you land a gig where that’s the case. For the most part, bosses are just fine. Some are just mediocre and more or less tolerable. Some are good and make work a nice place to be every day. But then, in rare instances, you come across a boss who’s truly  awful. A terrible boss can ruin your life and derail your career. Do you despise your relationship with your boss and wonder if maybe you’re overreacting? Read on for 6 of the most common awful boss behaviors. If you recognize more than 2 of these, it might be time to look elsewhere for work to save your sanity.1. They micromanage every little task.Bosses are supposed to hire people they trust enough- based on their skills and experience- to do the job they’re hired to do. Then, they’re supposed to leave you a bit of room to actually do your job, rather than breathing over your shoulde r and confusing things- or just stressing you out. A good boss eases up and lets you fly. A bad boss attaches himself to your every move, all the time.2. They always take credit for others’ successes.Taking credit for the ideas of others is never a good habit. It’s especially vile in a boss, who is supposed to nurture their employees and help them achieve. If your boss likes to claim the credit for something you had a heavy hand in and bask in the glow of accolades after a success, that means she’s getting in the way of your limelight. It’s not just unfair, it’s detrimental to your career.3. They’re never satisfied with anything.No matter how many expectations you meet or succeed, it’s never enough for your boss. She finds a way to demean your efforts or to belittle them. She’s always wanting more. There never seems to be any room for positive feedback or recognition because the goalposts are always moving. If you stick around too long, your self esteem is going to drop dangerously low.4. They constantly manipulate you, but never enough to cross a line.Often, a terrible boss comes to understand just how much criticism you can handle without snapping, breaking, or quitting.  and sticks to that limit- again and again. He knows if she takes too much from you too fast, you’ll simply quit. But if he beats down your self worth and builds you back up, again and again, you might stay. Don’t.5. They hoard the knowledge and the power.Everything flows through your boss. All things are CC-ed. He has his hand in every project. And, most importantly, he is the only one with enough knowledge to see the big picture, or the whole scope of a project. If you and your team members are laboring in the dark, chances are your boss is keeping you there.6. They’re easily threatened.Anytime your boss’s authority is tested, she flips out. This is not normal behavior for a boss, particularly if that â⠂¬Å"threat† is just someone having an idea, or a conversation that doesn’t include her. Horrible bosses see other people’s successes as their losses. If your boss flies off the handle whenever she’s not #1, you’ll find yourself trying to hide your accomplishments, which is  not a way to build a career. Consider talking to human resources, requesting a transfer, or looking for a new gig if possible.

Tom Peters on Uncertainty Essay Example | Topics and Well Written Essays - 500 words

Tom Peters on Uncertainty - Essay Example There is a great challenge to management to meet the changing landscape and capitalize on the new economies. Tom Peters was telling us that there is a brave new world of business and our management structures and organizations must be equipped to meet the uncertainty of the 21st century. The post bureaucratic era has introduced many new norms for institutions and business. While the staid structures of clearly defined hierarchy may have served history well, they can not keep pace with the speed of change in today's world. By understanding that we are faced with continual uncertainty, organizations can restructure to take advantage of that change. Networking and team concept approaches can offer the ability of an organization to react and act in the face of sudden change. While many opportunities will exist, it is the organizational structure most adept at handling change that will define the success from the failure. The globalization of capitalism has also presented new markets and manufacturing bases. Yet, here again the organization is faced with uncertainty. The firm may find itself embroiled in international politics or environmental issues that may threaten to sink their investment. The venture must be structured in such a fashion that they can withstand the assault of the unknown.

Hitler's greatest mistake Research Paper Example | Topics and Well Written Essays - 750 words

Hitler's greatest mistake - Research Paper Example Hitler was very much overconfident about invading Russia. The troop was not provided with winter clothing or equipments. More than half of Germen troops were frozen to death. The invasion was started on three fronts, in the south towards the Ukraine, in the north towards Leningrad, and centre towards Moscow. The moves were initially considered as successful advances. Within few days the Luftwaffe achieved air supremacy. German troops started encircling Russian defenders. Nazi legions soon conquered 1200 tanks and 600 big guns. They also gained more than 150,000 prisoners. Hitler attempted to control Russia to a great extent. Their crucial aim was to gain control over Leningrad-Moscow-Volga line. Germany’s three-pronged invasion was intended for seizing production areas in Ukraine and the Donetz basin. Germany’s plans were to acquire mineral deposits, oil and grain. They attempted to capture the Black and Baltic seas. Russian citizens were encouraged to accept the ‘scorched policy’. They were instructed that if they were forced to evacuate from their place they should not leave anything behind. They should evacuate fully. Germans at the same time started feeling trouble as weather was becoming disadvantageous for them. Russian partisan groups were gaining strength as they began imposing big tolls on supply convoys. Germans gained control over Riga, Smolensk and Kiev. They invaded Stalingrad to acquire the oilfields of Cacasus in August 1942.

A brief history of science education in ghana from the colonial era to present day Essay Example for Free

A brief history of science education in ghana from the colonial era to present day Essay Science education is the cultivation and disciplining the mind and other faculties of an individual to utilize science for improving his life, cope with an increasingly technological world, or pursue science academically and professionally, and for dealing responsibly with science related social issues (Akpan, 1992). Ghana, formerly known as the Gold Coast, was the first African country to the south of the Sahara to gain political independence from colonial rule in 1957. This former British colony of 92,000 square miles (about 238,000 square kilometers) shares boundaries with three French-speaking nations: the Cote dIvoire to the west, Burkina Faso to the north and Togo to the east. The Gulf of Guinea of the Atlantic Ocean is to the south of the country. EARLY HISTORY OF EDUCATION BEFORE INDEPENDENCE As was the case in many colonies during the early colonial period, the main goal of education was to ‘make civilization march hand-in-hand with evangelization’ (Anum –Odoom, 2013). This statement gives a clear description of how education in Ghana was implemented at that time. The formal, western-style education in Ghana is directly associated with the history of European activities on the Gold Coast The Portuguese were the first Europeans to arrive at the Guinea coast in 1471. Their intention to establish schools was expressed in imperial instructions that, in 1529, encouraged the Governor of the Portuguese Castle at Elmina to teach reading, writing, and the Catholic religion to the people. It is imply proven that the Danish, Dutch and the English merchants also set up schools in their forts and castle to educate their mulatto children by native women. Unmistakably linked to the implementation of formal education in Ghana with the Christian missionaries, who realized that in order to spread the word of God, they needed well- educated local assistants. Following the consolidation of the coastal region as the British Gold Coast Colony, the administration became more aggressive in pursuit of its educational policy. This was precipitated by the British purchase of the Danish property at Christiansborg in 1850 and the Dutch Elmina Castle in 1872. To help redress problems faced by the mission schools—such as training local teachers and improving the quality of education—the administration made grants to both the Wesleyan and Basel missions in 1874. In the Educational Ordinance of 1882, government grants to denominational schools were made dependent on an assessment of the level of efficiency. The schools receiving grant-in-aid were defined as government assisted schools, but their primary funding was to come from the missions themselves and from other private sources. On the Gold Coast, the appointment of Brigadier General Gordon Guggisberg as governor brought its own advantages. During his tenure from 1919 through 1927, Governor Guggisberg initiated several major developmental programs that included educational improvements as a critical ingredient in his construction of a modern Gold Coast. While the previous administration had seen the provision of elementary schools by the various Christian missions as adequate, Guggisberg was of the conviction that the current system could not sustain future developments. In fact, only a few months after his arrival, the governor presented a 10-year development plan for the Gold Coast. Among other things, funding was aggressively sought for post elementary education for boys and girls. Even though the administration proposed a technical college for Accra, the Prince of Wales College (now Achimota College) was the real trophy of the administrations educational program. This non denominational school catered for students from kindergarten to the pre university level. THE BIRTH OF SCIENCE EDUCATION The inadequacies inherent in the system of education were observed in the post-World War I appeal made by the Foreign Missions Conference of North America to the Phelps-Stokes Funds for a review of the state of education in Africa. The Phelps-Stokes Commission on Africa issued reports in 1922 and 1925 in which educators were criticized for inadequately catering to the social and economic needs of the continent. The commission of which James Emman Kwegyir Aggrey was a member, called for instructions in the mechanical operations necessary for the improvement of the condition of the mass majority of the people. This included science education and character training. The Phelps-Stokes funds founded in 1920, is an African Education Commission represented one of the early attempts to link black Africa with Negro America. The attempt to forge this link represented a concerted policy on the part of a number of missionary and philanthropic groups in the United Kingdom and the United States to draw attention to what seemed to be analogous situations-politically, socially, and economically. Ghana is said to be the first independent sub-Saharan African country outside South Africa to embark on a comprehensive drive to promote science education and the application of science in industrial and social development (Anamuah-Mensah, 1999). Science Education after Independence After Phelps- stokes commission had pushed for the birth of science education in Africa in general and in particular, Gold Coast, there has not been any clear cut national policy for science education in Ghana up to date (Ahmed, 2013). Dr Kwame Nkrumah who aimed at achieving Free Compulsory Universal Basic Education instituted an Act called 1961 Act, (Act 87) . This Act was to make Basic education free and Compulsory and anyone who fails to send his or her child to school was made to pay a fund by the Minister for education. The education system at that point consisted of six year of primary education, followed by four-years of secondary education. At the end of the four years suitable students went on to do a two-year sixth form course that could lead to a three year University course. Students, who were not suitable to continue, completed two- year of pre-vocational classes. The Nkrumah government encouraged the learning of science by instituting a special scholarship scheme which enabled science and agriculture undergraduates to enjoy scholarships a little higher than those of their counterparts in the humanities. This facility was withdrawn after 1966. Science and mathematics teachers were also paid a little more than their colleagues in the humanities. (Djangmah, 2007) The Reforms The seven year development plan instituted by Dr. Kwame Nkrumah was short lived. The system was later regarded as too long and too academic. Thus Dzobo Education Reforms of 1974 saw a reform of the system, instating the Junior Secondary School (now Junior High School) on an experimental basis. The Junior Secondary School introduced practical subjects and activities allowing students to acquire occupational skills, which after an apprenticeship lead to the qualification for self-employment. Due to a wide range of factors such as the economic decline, bureaucracy and sheer lack of interest the JSS-system never went beyond the experimental phase. By 1983 the education system was in a state of crisis. It faced drastic reductions in Government financing, lack of educational materials, and deterioration of school structures, low enrollment levels and high dropout rates. With the assistance of several development partners (World Bank, Department for International Development (ODA) and international grants) the education system was reviewed and proposals were implemented in 1987 known as Evans-Anfom reforms. In 1987, Ghanas Ministry of Education introduced a restructured educational system that gradually replaced the British-based O-level and A-level system. The transition was completed in June, 1996, when the last class took A-level exams. The last O-level exams were administered in June 1994, although a remedial exam was offered through 1999 (Keteku, 2013) The 1987 Reforms had strengths as well as weaknesses. One of the strengths was that it provided a comprehensive Basic Education which improved access to education for more children of school-going age. Junior Secondary Schools were provided throughout the country and this helped to increase literacy levels. The reform also introduced Continuous Assessment which formed part of the final examination. This ensured that internal assessment in schools was included in the final examinations and this ended the single-shot examination existing in the old system. The Anamuah-Mensah Report recommended similar structure of education just like the Evans-Anfom Report of 1986. The difference was the inclusion of two (2) years of Kindergarten education as part of Basic Education and Apprenticeship training for leavers of the Junior Secondary School who unable to or do not want to continue in the formal sector. The implementation of the Anamuah-Mensah Reforms began in September 2007, and it was faced with initial problems. These problems included delay in the supply of syllabuses and textbooks for the smooth take-off of the programme, and teachers were not adequately prepared in terms of training to implement the reforms. These problems were later dealt with as the implementation of the reforms progressed. The next major problem being anticipated is the inadequate classrooms and other facilities as students will enter the fourth year of Senior High School in September 2010. The Way Forward For Science Education Promotion of science education in the country will depend on three drivers of change, namely, funding, teaching and interventions, and research (Akyeampong ,2007) Funding Knowledge is not cheap. Science, technology and mathematics knowledge required to move the country into the knowledge society can never be cheap. Government’s commitment to science education should be demonstrated in the level of resources allocated to science and technology. Laboratories and workshops in the schools, teacher training colleges, universities and polytechnics should be well equipped and new ones constructed to take into consideration the increasing student population. Research The knowledge society thrives on the creation of new knowledge. Research provides the means by which new knowledge is created. Resources, both material and human, for research in science and technology are woefully inadequate or non-existent. This has had a profound effect on the development of post graduate research in the universities. A number of measures need to be taken to strengthen research in science and technology in order to meet the demands of the country. The following are being suggested: †¢Research in research institutions and the universities should be adequately funded. †¢Most researches carried out in the universities are those that interest the researchers and are hence supply-driven; the Government should challenge our scientists and provide funds to carry out research on problems confronting the country. This can be done through the provision of research funds to be competed for by all scientists in the country. †¢Establish a National Science Research Facilities Centre equipped with world class specialized facilities which are normally expensive and therefore beyond the means of single institutions, to provide opportunities for Ghanaian researchers to carry out scientific research and development and retain local researchers as well as attract foreign ones. †¢To improve the quality of science education at all levels, research in science and technology should include research on teaching and learning science, technology and mathematics. †¢Institute special awards for best researchers and science teachers. This could be termed the President’s Award for Science to be given annually. We need to celebrate achievement. †¢Set up a formal scheme for mentoring the Youth- This is critical to the development of a career path in science for the youth. Mentors excite interest in junior colleagues and help them to â€Å"walk the path†. This experience is however rare in the universities. These days, newly recruited scientists struggle to keep afloat with little or no support. A formal mentoring system should be established in all institutions to ensure that young scientists recruited into the universities or research institutions are attached to professors and senior scientists in their fields of study to receive advice and support. The mentoring can take the form of joint research, publications and presentations at conferences and seminars. †¢To raise the level of awareness of science and technology innovation (research) and foster a synergy among education, industry and research institutes, a project referred to as SMART MOVES in some countries should be established in secondary schools. This project will involve encouraging schools through visits, presentations and seminars to work on problem solving projects with support from the community. The projects will be assessed and students with innovative and creative projects will be invited to present their projects at a Junior Scientist Conference which will be attended by senior scientists who can later act as mentors for the students. Prizes will be given to students based on the quality of project and presentation. The Ghana Academy of Science and Arts can take up this. Conclusion The vision of the National Science and Technology Policy is: â€Å"to support national socio-economic development goals with a view to lifting Ghana to a middle income status by the year 2020 through the perpetuation of a science and technology culture at all the levels of society, which is driven by the promotion of innovation and the mastery of known and proven technologies and their application in industry, and other sectors of the economy†. (MEST, 2000) This vision can become a reality when science education is given a boost at all levels of education. It has been suggested that the promotion of science education hinges on three pillars – funding, teaching and intervention, and research. Without adequate funding, quality teachers, supportive intervention activities and research to illuminate our understanding, science education will have no impact on the everyday lives of Ghanaians; and the observation made by the National Development Planning Commission will remain true. Our national vision for science and technology will be therefore be meaningless. REFERENCES Ahmed, M. (2012). Ghana to launch National Science policy. Retrieved 4th October, 2013, from http://www. ghanaweb. com/GhanaHomePage/NewsArchive/artikel. php? ID=235350. Akpan, O. E. (1992) Toward Creative Science teaching and learning in West African school. Ghana: catholic Press Akyeampong, K. (Centre for International Education, University of Sussex, England) in his lecture on â€Å"50 Years of Educational Progress and Challenge in Ghana†, at Parliament House, London, England; 2007 Anamuah-Mensah, J. (1999). Science and Technology Education in Ghana. A paper delivered at the National education Forum on the theme: Towards Sustaining an Effective National Education System, held at the Accra International Conference Centre, Accra, 17-19th November. Anum-Odoom, A. K. M . Educational Reforms in Ghana, 1974-2007. Retrieved on 12th October, 2013, from http://www. ghanaweb. com/GhanaHomePage/blogs/blog. article. php? blog=2091ID=1000004125- Djangmah, J. S. Clarifying Ghana’s national vision for the application of science and technology to development. Retrieved on 12th October, 2013, from http://www. ghanansem. org/index. php? option=com_contenttask=viewid=234 Keteku, N. W (EDUCATIONAL REFORM IN GHANA: THE SENIOR SECONDARY SCHOOL). Retrieved 10th October, 2013, from http://www. bibl. u-szeged. hu/oseas_adsec/ghana. htm Ministry of Environment, Science and Technology (MEST) (2000). National Science and Technology Policy Document. Accra: MEST.

Filippo Brunelleschi Essays -- Classical Italian Architecture Italy Es

Filippo Brunelleschi Fillippo Brunelleschi is famous for such ideas and projects as the â€Å"Cupola of the Duomo† in Florence and for the way he convoluted forms of classical architecture according to the new spirit of his age. In the Florentine workshops he was trained as a sculptor and goldsmith and in 1401 he became well known by winning a competition for the second door of Baptistery â€Å"Ex Aequo† with Lorenzo Ghiberti, who was commissioned to carry out the work. The Bargello Museum holds the panels of the â€Å"Sacrifice of Isaac† that the two artists carried out for this competition. It is believed Brunelleschi most likely spent the next three years studying sculpture and architecture with his friend Donatello in Rome. In 1401 he joined the Guild of Goldsmiths. However, his interest in mathematics and ancient monuments sent him toward the direction of architecture (Lombroso 1). Starting in 1409, he worked on the Santa Maria del Fiore’s construction and was immediately attracted by the cupola’s problem; in 1418 his design won the competition and he was put in complete charge of the building works in 1423. The completion of this important construction and a special design technique that made it possible to create the huge cupola’s curves without a supporting framework, presumed most of his life. This formed the basis of Renaissance architecture. In 1434 the main structure was finished and then the lantern completed it by 1436 and finally the four tribunes in the apse in 1438 (Lombroso 2). During this period Brunelleschi also worked on the Pazzi Chapel in the Cloisters of Santa Croce in 1430, the Spedale degli Innocenti in 1424, the reconstruction of San Lorenzo in 1423, on the design for Santo Spirito in 1436, and finally t... ...ful monarchs that finally succeeded in gradually unifying each country. England’s unity came under Henry VII while France was united around the time of the death of Louis XI in 1483. Major ideas of the Renaissance also began to influence the cultures of England and France. The reign of Queen Elizabeth I was perhaps one of the most culturally rich times for England during the Renaissance. Shakespeare’s plays and works were also written and glorified during this time (Cedar Rapids 7). Works Cited: Cedar Rapids Community Schools, Government of the Renaissance. Web. 3 April 2015. http://www.cr.k12.ia.us/Renaissance/government.htm Encyclopedia4U.COM, Leone Battista Alberti. Web. 3 April 2015. http://www.encyclopedia4u.com/l/leone-battista-alberti.html Megavia Lombroso, Filippo Brunelleschi. Web. 3 April 2015. http://www.mega.it/eng/egui/pers/fibru.htm

How It Affects Economic Growth Essay

In my opinion, supporting and promoting IT investment is one of the best ways to promote economic growth and stability with minimal side effects such as inflation, and easily overcome hurdles like unequal income distribution. While I don’t think you can really influence people’s personal ownership of computers, I do believe that offering tax incentives for IT investment and development will increase overall GDP, lower unemployment, and ensure an economically stable future. First and foremost, investment towards information technology increases productivity, and makes workers more efficient in what they do. With more resources such as faster word processing, 3D Model Rendering, and instantaneous transfer of data over the internet, laborers in every facet of the economy benefit from technology and enjoy greater productivity as a result. This increase in productivity means more products and services are produced with less time invested, and this means that Gross Domestic Product can go up. Furthermore, GDP is often defined as a function of both Capital and Labor. It is widely acknowledged that GDP growth can be measured by K/L, or Capital divided by Labor. Clearly, then, if each worker is using a higher value of capital (here in the form of fancier computers etc), then GDP is sure to go up. The concern then becomes, â€Å"what about inflation?† Surely, if GDP goes up, inflation will follow, no? Not quite. The accompanying graph gives us a rough idea of why. This increased efficiency will shift the Philips curve inward, meaning that for every unemployment rate, there is less inflation. More IT investment will mean that we will require more service technicians, troubleshooters, software programmers, etc, and we will see unemployment go down. Also, with more children learning about IT, they will also be more likely to get jobs when they grow up. When unemployment goes down, though, we typically see that there are less available â€Å"desperate† workers, and thus workers will have more power to bargain collectively. They will get wage increases, which will be passed on to consumers in the form of higher prices on final goods and services. This is offset by increased efficiency, as it takes less worker hours to make those products and services. As the Philips curve below shows us, the decrease in unemployment WOULD cause higher inflation, but because of increased efficiency, this change in inflation is offset. It is important to note the short run and long run effects of tax incentives on both the macro and micro levels. Here is a graph to get us started: We know that in the short run Demand shifts out as IT becomes more and more necessary. Supply shifts out because manufacturing costs go down, and thus existing firms will produce more at every price. These reductions to cost shift MC and ATC down; we don’t’ know how much each of these shifts is, though. We don’t know what P2 is, but we know that costs go down, so there is abnormal short term profit, and we know that each firm is going to produce more. In the long run, more firms will enter (shifting supply out further) until each player in the market is operating at their lowest cost on the ATC curve, which is the point where long run profits are equal to 0. We know that long run market quantity is greater because there are more firms in the industry, and we know that each firm produces in the long run what it did before all the shifts. Each firm is producing more in the short run than in the long run. Assuming that the government offers tax incentives to BOTH SUPPLIERS AND BUYERS of IT, we can expect to see the same demand shifts and supply shifts as we did in the 90s, when demand shifted out and the cost to produce came down. The tax rebates to suppliers means a reduction of cost (same as in the last example) and the tax rebates to buyers will make the price they have to pay lower, which will increase demand. One of the few drawbacks to the subsequent increased IT spending, of course, is the negative effect on the environment, as computers become obsolete quickly and are usually just thrown out. In my opinion, the environmental effect is definitely a huge drawback to increased IT investment. I believe that the government should give further incentives to companies who donate old or â€Å"B-stock† products to schools (preferably those in bad areas) or charities when they buy new ones . Donating these slightly flawed or last-year-model computers to schools would be an investment in human capital, which would increase GDP in future generations, as children become more tech savvy and productive with computers. Since the government is reducing the cost of production with tax incentives, I think they could get away by contrasting these incentives with slightly stricter environmental regulations as far as waste goes. They should set requirements on the packaging (which is created solely to be thrown out) that comes with IT goods, and should give even more incentives to companies that collect and recycle re-usable components such as circuit boards, plastic cases, and semiconductors – all components that are not biodegradable and are a large part of the junk filling our nation’s landfills. Another set of short and long term effects you must consider is the effect of tax incentives on those already involved in the market: IT workers. Again, we have a graph to help us visualize these effects. For this discussion, because of inflation, we must assume that we are talking in terms of real dollars, and that these wage prices are adjusted for inflation. In the 1980’s (short run), as IT became more important to industry, we see the demand curve for IT work shift outward, causing an increase in price and quantity as more qualified people started doing IT. In the long run, more competitors enter and the number of CS majors doubles; supply shifts outward, but we’re not sure by how much. We know that real wages go back down, but we don’t know if they are above, at, or below the original prices. We just know that they are decreasing, and that the overall quantity is much higher. The last major concern would be the â€Å"Digital Divide† – the concept that low income families do not use computers and thus are isolated from their potential benefits. This â€Å"digital divide† essentially means that poorer families have less access to the computer and tech skills to compete in the modern job industry, such as word processing and online research. They also have less access to online educational resources, and thus have less human capital. This means they are less likely to rise out of poverty, and are at a disadvantage. Those fortunate enough to be able to afford computers & internet access will get more educated and richer, and those who are not fortunate enough get poorer. I personally am against racial discrimination in all forms, and I think targeting out minorities and saying â€Å"here, you need a computer† is wrong. I do, believe, however, that there should be some sort of program to give less fortunate children of all ethnicities the IT skills and access to computers that they will need to function in the modern labor market. This is where my idea of offering tax incentives to companies that donate â€Å"last year model† computers to charities or schools in bad neighborhoods could really benefit these people and help them accumulate human capital. I think that offering tax incentives to people who put computers in their home will be too difficult to manage, and I also think that in many cases, people without the means to get a good job (no technical background) will not be able to afford a computer either way – thus, it’s a vicious cycle. Additionally, I think people who can’t afford $40/mo for DSL are in this predicament because they don’t have technical skills, and thus, probably don’t value technology as much as they should. They probably still won’t be interested in broadband. I think the president’s broadband initiative should focus more on getting faster internet and more technical training into schools, so that the next generation, who still has the desire and patience to learn about computers, can do so at an early age. Overall, you can see that there is a long list of benefits, and a short list of easily overcome problems with increased investment. In fact, even the Fed benefits. Normally, increased investment would make the Fed have to increase interest rates to prevent inflation and â€Å"cool off† the economy. IT is unique, however, in that it also provides greater efficiency, thus shifting the curve as discussed earlier. I would argue that it makes the Fed’s job easier – it’s promotes economic growth and employment, without jeopardizing economic stability. All in all, I say that giving tax incentives to producers and suppliers of IT goods and services is a great plan!

Under the Bridge Song Analysis

15 April 2010 Essay 2: Poetry â€Å"Under The Bridge† Under the bridge is a song by Red Hot Chili Peppers, written by vocalist Anthony Kiedis. Keidis reference to â€Å"bridge†Kiedis use of imagery in the lyrics to this song communicate a dark time in his life but also as a listener we can relate with a difficult time in our own life. The symbolism used by Kiedis in reference to his feeling of solitude and long battle with drug addiction. Rhyme and rhythm are two of the main features in this song.The rhythm affects the whole mood, tone and meaning of the song. The melancholy can be felt in the first stanza, â€Å"Lonely as I am together we cry. † Kiedis has chosen different methods to give the song specific sounds that affect the pace and structure of the rhythm. The speed of the song begins quite slow not too intense but slowly the tempo picks up as he describes, â€Å"I don’t ever wanna feel like I did that day. † The feelings of loss bring him to depression and remind him of his struggles with drug abuse.The reference in the third stanza â€Å"take me to the place I love take me all that way† can suggests that Kiedis is taken back to the feeling of being high on drugs. Metaphorically he is attempting to overcome drug addiction but can’t help loving the feeling he gets when he is high. â€Å"The loneliness that I was feeling triggered memories of my time with Ione and how I'd had this beautiful angel of a girl who was willing to give me all of her love, and instead of embracing that, I was downtown with gangsters shooting speedballs under a bridge. (Kiedis 204) Kiedis memory of such a time stimulated his response of loneliness as he is doing so in song to his listeners. Drawing back from the people he was once so close with gave him an overwhelming feeling of loneliness and solitude, as he described, â€Å"Sometimes I feel like I don't have a partner sometimes I feel like my only friend like my only friend is the city I live in the city of Angels† (Peppers) The descriptions of the city being his only stronghold during this difficult ime are realized in his city of Los Angeles which he feels would never leave him alone as some of his relationships at that time. The city is stable, and he is able to depend on her being there to support him. He refers to the city as his â€Å"companion†, and he does not have to hide from her because she already knows his deepest secrets but has yet to abandon him. It's interesting to see the different interpretations to this song, but I do believe Kiedis was clearly recounting his drug addiction in a very personal yet abstract manner.Revealing the solitude one has to endure when they find themselves in such a state. My understanding of the song shows the contemplation, withdrawal, and the acceptance of taking a dark path in life. Literature can be subtle or obvious, used carefully or carelessly. The repetition of the third stanza signifies mea ning and creates a strong sonic effect to the listener. Kiedis use of this can be found in the chorus, â€Å"I don't ever wanna feel like I did that day take me to the place I love take me all the way. (Peppers) The text states, â€Å"We all hear sounds differently depending on the meaning and context. † (Beiderwell 522) The feeling this song gives me may be totally different that it may give someone who has experienced an addiction or feeling of despair. In general, the lyrics deals with particular things in concrete language, since our emotions most readily respond to his emotion and expressions. From Kiedis particular situation, the listener may then generalize by implication from the particular. â€Å"She sees my good deeds and she kisses me windy and I never worry now that is a lie. (Peppers) The use of personification occurs here when he describes inanimate objects as human that is, giving them human attributes, powers, or feelings. He is not literally speaking of a p erson but showing his connection with the city he loves so much, as the only person he feels loved by. Images suggest meanings beyond the mere identity of the specific object. (Purdue) Poetry â€Å"plays† with meaning when it identifies resemblances or makes comparisons between things, such as the Los Angeles being his only friend.In the last stanza, â€Å"Under the bridge downtown is where I drew some blood under the bridge I could not get enough under the bridge forgot about my love under the bridge I gave my life away† (Peppers) Kiedis is recounting a low point in his life where he feels he surrendered his life to this addiction to drugs. This use of imagery is most valuable as a mode of perception that assists the listener to see around and to see the often conflicting interpretations that come from our examination of life.In other words his message is most certainly concrete and particular it's implied by the images of him under this bridge drawing blood which is what heroin addicts do. Works Cited Beiderwell, Bruce and Jeffrey M. Wheeler. â€Å"The Literary Experience. † Beiderwell, Bruce and Jeffrey M. Wheeler. The Literary Experience. Boston: Thomson Higher Education, 2008. 217-229. Kiedis, Anthony. Scar Tissue. New York: Hyperion, 2004. Peppers, Red Hot Chili. â€Å"Under The Bridge. † Blood Sugar Sex Magik. cond. Anthony Keidis. By Anthony Keidis. Los Angeles, 1992. Purdue, Owl. Owl Purdue. 21 April 2010. 07 April 2010 .

Becket essays

Becket essays Henrick Ibsen once said that, The strongest man in the world is he who stands alone. A man with the greatest power and strength is the loneliest man. There is rarely anyone who can match his capability and ability. Even though the man receives respect from people around him andis inaplace of exbit these characteristics are King Henry II in Becket by Jean Anouilh and Atticus in To Kill a Mocking Bird by Lee Harper. In Becket, King Henry II is the most powerful man in England but he feels lonely. Due to some of the kings actions, he has experienced loneliness. King Henry appoints Beckect, his one trues friend, as archbishop of Canterbury. Ironically, King believed this would strengthen their friendship but it lead to his loneliness. So the strongest man in Also, in To Kill a Mocking Bird, Atticus experiences loneliness due to his actions. He is a respected lawyer and in his town. When Atticus jumps to aid of a young black man in Alabama, the other characters in the book, turn against him. Unfortunately, Atticus seems to be the only one who has these feelings about the man. Due opposing views, Atticus is not looked upon as the same man and there for he feels lonely. Both Becket and To Kill a Mocking Bird, demonstrate what Ibsen said in his quote. King Henry II and Atticus are strong men who ...

Essay on Yolo or Carpe Diem

Essay on Yolo or Carpe Diem â€Å"Yolo† is a popular acronym used these days as a take on â€Å"Carpe Diem,† or seize the day. It stands for â€Å"You Only Live Once.† It has implications of it being okay to make stupid mistakes because each and every one of us lives once, we think. Life is short, we all know that, and we – well, most of us – want to live life to the utmost fullest, in turn getting everything we can out of life. After all, it is a wonderful, beautiful gift: Life. But we didn’t ask for it. As a matter of fact, it takes some people a lifetime to figure what it means to be alive. â€Å"Yolo† may be a term used by the youngsters of today, as heard in songs by Adam Levine and Drake, but it carries meanings and implications that are universal and everlasting. The phrase is too often used by the hipsters of today in the United States to make excuses for their dumb mistakes. The phrase will never catch on and be used ubiquitously by the American people – or other nationalities, either – because it is cumbersome to say and even harder to care about and remember. To the ordinary person, it sounds like some frozen yogurt brand nobody wants to try, or some variation of the color yellow. But the acronym has good intentions. â€Å"You Only Live Once† reminds one of a hopeful youth, of seeing and wanting the best in life, of seizing the day because tomorrow is not promised – nor is even the next moment. Nonetheless, the wrong people seem to be using the term. They are the slackers who don’t take blame for their impulsive, risky decisions, and then when the problems arise from the decisions, they blame it on â€Å"You Only Live Once.† But it’s just one more way to enable these kinds of behaviors where judgment is lacked. Also, the mentality attached to this word provides people more reasons not to blame themselves for when they make a monumental mistake. They blame it on â€Å"Life† and not their own erroneous decision. What does this create? A bunch of cultures which don’t hold themselves accountable for their actions. SAMPLE ESSAY ABOUT HAPPINESS So this â€Å"Yolo† mentality is not so cut and dry. It is good and bad. It is both a hindrance and an empowering philosophy, depending on the person using it and how they use it. But it is being used nonetheless. Most people want to get all they can out of life, and so, in this case, it is quite motivating. â€Å"Yolo† can be inspirational to those trying new things – who want to take calculated risks, meet new people, take exciting trips, etc. It can mean understanding what it means to be born to die – and in between, there are opportunities to make the most out of this crazy life. In between birth and death, there is of course suffering, problems, the death of others, bad people and bad experiences – but there is also love and hope and family and beauty. Unfortunately, this â€Å"Yolo† philosophy does not seem to focus on the most optimistic aspects of life. It seems more that this philosophy only provides excuses for young rich kids to account for their immature, impulsive, selfish actions. The phrase will never be used by the masses like â€Å"Carpe Diem.† It is one more excuse for spoiled American kids to put off growing up and becoming responsible, productive adults. It is really quite a pathetic, irritating notion to people who don’t have the luxury of staying children their entire lives, putting off adulthood because it doesn’t suit them. â€Å"Yolo† is an irritating acronym, one that is not only confusing to most people but one that will just never catch on. Only the young hipsters will use it, and they are not â€Å"mainstream† anyway.

Evaluating Organizational Behavior Research Paper

Evaluating Organizational Behavior - Research Paper Example This paper illustrates that through observing from both internal and external perspectives, individuals understand why people tend to behave in a particular manner within a team environment. PepsiCo. Inc is a multinational corporation from the United States (USA) that deals with food and beverage with its headquarters at New York in the USA. The company engages in manufacturing, marketing as well as a distribution of beverages, grain-based snack foods, as well as other products. The multinational engages in business operations throughout the continent. A focus on the company’s human resource policies proves essential to understanding its organization behavior. With distribution channels and manufacturing units all around the globe, the company realized the reason for successful operation is achieved through enhancing effective human resource policies. The code of conduct and Human Rights Work Policy of the company outlines guiding measures that ensure an embodied companyâ€⠄¢s policy that enhances in dealing fairly and honestly with the company’ s associates regarding wages and benefits as well as other employment conditions. The company provides equal opportunities for associates without tolerance for discrimination and thereby ensuring compliance with all applicable regulations, laws as well as other employment standards. Consequently, the company maintains a â€Å"Speak Up† policy line operational for twenty-four hours and an internet portal to enhance reporting of any alleged or suspected human rights abuses. The company respects workers dignity in the workplace as well as ensuring the associate's rights to personal security, clean, safe, as well as the healthful workplace. The company also provides associates freedom from harassment and abuse of al manners. Fair treatment and honesty are consequently applied in relation to workers wages, benefits and all conditions of employment. The associates’ right to freedom of associatio n also remains a significant point of consideration within the company.

Isolated By The Internet Essay Example | Topics and Well Written Essays - 750 words

Isolated By The Internet - Essay Example The positive outcomes of the internet revolution are many. But there are negative aspects also. Stoll brings forth researched viewpoints of the psychologists and personal observations supported by documented studies in support of his stand. Stoll quotes facts from the research conducted by Carnegie Mellon University psychologists Robert Kraut and Vicki Lundmark. (393)Some top-ranking computer companies aided the research project but the outcome is not to their favor. The findings are â€Å"[a]fter following the study group, the psychologists found an average increase in depression by about 1 percent for every hour spent online per week.†(393)Another finding is, social relationships online develop at the cost of the individual to individual social involvement. Good and bad effects of internet In a well-written article, Stoll presents good and bad effects of internet and how people are isolated by it, by too much dependency. He mentions how â€Å"one friend tells how she found a support group for an obscure medical condition.†(392) It is a well-known fact that many youngsters have entered into wedlock by corresponding/chatting through the internet. Wired family members are able to keep in touch through email and such communications have become popular. Stoll admits without hesitation â€Å"the electronic virtual community is a positive social development† (393). Internet causes degrading communication skills according to psychologist Kimberly Young. (396)He also uses College and University reports to support his viewpoints. Stoll employs UCLA (University of California at Los Angeles) loneliness Scale for Epidemiologic Studies Depression Scale to show that on average depression increase 1 percent for every hour a person is online per week (393). This is an alarming finding. The limitations of the advantages of internet Stoll is an expert on computer security and is well-versed about the technical aspects of the use and impact of computers in t he day to day life of an individual. He makes clear the isolating factors and states that internet offers anonymity. To manage too many relationships demands time and energy and the chance of developing meaningful relationships are too little. Non-personal contacts within the information highway are fine for some time, video games offer a release from reality and a distraction from depression, but they are not long-term solutions for the betterment of the society. People make friendships with many through the internet, without knowing why for they are doing so. Every relationship should have a purpose, and with too many contacts, the purpose is lost. Thus, one addicted to the internet, one develops complications in personality. Control technology, otherwise it will control you Internet use has caused many new social and psychological conditions. The issue with us is we take the benefits of the technological progress and advantages of the internet revolution for granted. Technology c an be an important tool in providing plenty and prosperity to the life of an individual in monetary terms, but one must accept and adopt it in suitable increments, to get the real benefit. If your gain is at the cost of happiness of your family life, it is not good to chase such gains. Stoll urges people to consider the harms of internet use from the viewpoints of children and its overall impact on family life. It is causing dent in the family values, reducing the time of personal interactions, and distances one from the realities of life. Many office-goers bring their work home and have no time to interact with children. Their playtime is robbed by the office files and procedures and the

HISTORY From Poverty to Social Exclusion Essay Example | Topics and Well Written Essays - 500 words

HISTORY From Poverty to Social Exclusion - Essay Example (NEW YORK TIMES 1909) A wealthy businessman, Seebohm Rowntree is well known for his in depth analysis of poverty. When concentrating on this particular time period, he stated that in the 1890s, it was low wages that was the major cause of poverty in Great Britain (ROWNTREE 2008). The problem of unemployment was especially important in bringing about poverty in late nineteenth and early twentieth centuries. "More than one-quarter of the years from 1834 to 1911 were plagued by high levels of cyclical unemployment". If a worker was unemployed for more than a couple of weeks, he would find himself in economic distress, and would have to look for government support. (BOYER 2004) A very important factor that led to poverty was widowhood. In case of the death of a husband, women were generally left without any earning family member to support them. This problem arose because at the time, it was not as easy for women to get a job as it is today. The opportunity to get a job for women was easy in the textile centers of the country, but was negligible in the mining and industrial towns. In these areas, therefore, women became victims of acute poverty when left without husbands.

Cyclo-oxygenase inhibitors of human diseases

Cyclo-oxygenase inhibitors of human diseases Historical background Cyclooxygenase (COX) inhibitors are a widely prescribed group of antipyretics and analgesics worldwide and are important component in the treatment of inflammatory conditions. Although first COX inhibitor was discovered more than a decade ago their origin dates back to ancient Mediterranean descent1. Back and other body pains where treated using extracts of poplar tree bark and leaves of myrtle. Use of willow bark emerged far more lately and its first appearance was reported in England in 17631. As was later discovered, the essence of the willow bark possessing anti-inflammatory and antipyretic properties was salicin. Further modification of its structural properties allowed generation of salicylic acid that eventually was developed via Kolbe reaction using phenol1,3. In 1899 Bayer company went ahead in synthesising more susceptible derivative of it, acetylsalicylic acid and named it aspirin. Following this phenylbutazone (1949) and indomethacin (1963) came along however the mystery of mechanism of their action in the body was not yet developed. It was not known until 8 years later when an idea surrounding the synthesis of prostaglandins within body was revealed and for which a Nobel Prize in physiology and medicine was awarded (1982)1. It was proposed that first non-steroidal anti-inflammatory drug (NSAID), aspirin, acted upon inhibition of an enzyme that played role in utilising unsaturated fatty acids into biochemical molecules exerting their action in conditions such as inflammation, pain, and fever and platelet synthesis. It was accepted that during changes occurring within stimulated cells and tissues prostaglandins synthesis was taking place 1,3. Structure of COX was isolated in 1976 and its second isoform was confirmed around 14 years later by few different laboratory investigations; investigations which greatly allowed appreciating the nature of first nonselective cox inhibitors NSAIDs in the treatment of human diseases1. 1.1 The pharmacology and chemistry of cyclooxygenase enzyme Cyclooxygenase (COX aka PGG2/H2 synthase) belongs to the family of enzymes known as myeloperoxidases and it is the crucial enzyme in the synthesis of prostaglandins, prostacyclin and tromboxane A2 resullting from the conversion of arachidonic acid (AA) 2,4. This heme-containing COX enzyme is a bifunctional biocatalyst with two interconnected active sites: cyclooxygenase and peroxidase which action involves generation of hydroperoxy endoperoxide PGG2 via cyclooxygenase cycle (Fig.1.) into its reduced form of hydroxy endoperoxide (PGH2) (Fig. 2.) 2,4. Both isoforms of COX enzyme are expressed in endothelial, monocytic and renal cells with COX-2 being more profound in inflammatory and cancer tissues. Both enzymes are characterised by signal peptide, endothelium growth like factor (EGF) region, membrane in-bound domain, catalytic part, interface between monomers and N-linked polysaccharides residues2. The signal peptide in COX-1 consists of 23 residues whereas COX-2 has only 17. The EGF like region constitutes a major part of the interface and is not found in other myeloperoxidases. It is involved in Cys-Cys cross linked bridges with lack of Cys9 in COX-1 and Cys512 in COX-2. The membrane in-bound domain accounts for 33% of overall similarity and 24% of identity within membranous face. This domain is described as consisting of 4 amphipathic a helices that surround the entry to the COX site. The catalytic part is known to be the largest part of the enzyme with remained homology between other myeloperoxidases. 180Â ° rotation between subunits is preserved with chemical interaction between polar, ionic and hydrophobic moieties. Differences in residue positioning prevent heterodimerization and dissociation from facial interaction inactivates the enzymes overall catalytic activity 1,2,3,4,5. Figure 1. Mechanism of COX cycle in cyclooxygenase active site showing free radicals formation denoted by ? prior to PGH2 synthesis in POX pathway (not shown) 2. Attraction of hydrogen atom from Tyr385 by peroxyl radical of PGG2 allows for the regeneration of the steps of the reaction in the COX cycle of prostanoid biosynthesis. The coloured boxes are to indicate the origin of oxygen atoms. PLA2 phospholipase A2, S secretory, C cytoplasmic. Figure 2. A diagram summarising changes made to AA in the distinct active sites of the PGG2/H2 synthase and products formed via action of each catalytic active site 2. 1.2 The nature of cyclooxygenase inhibition in the human body Inhibition of cyclooxygenase action is desired in the treatment of human diseases. Not only because it suppresses the inflammatory production of prostaglandins in the conditions such as: dysmenorrhoea, rheumatoid arthritis, osteoarthritis but also because it prevents platelet aggregation, suppresses tumour growth and prevents cancer5. Until 1994 it was not clear by which mode, mechanism or process inhibition of COX was carried out. Just complexation studies between COX and flurbiprofen allowed insight into molecular basis of COX inhibition. The investigation led by Garavito and his colleagues proposed such model of inhibition. In his model it was suggested that the enzyme in question possesses long hydrophobic path that originates from in-membrane bound moiety up to the heart of the dimer subunit. Blocking this channel stops the endogenous substrate (AA) from binding hence possible intervention in the process of prostaglandins biosynthesis5. 1.3 The types of cyclooxygenase inhibitors in the treatment of human diseases There are several types of COX inhibitors available in the treatment of human diseases. The very first one, aspirin, is known to act through non-selective and irreversible manner. As this manner suggests aspirin binds to both types of COX enzyme by acetylating Ser530 residue upon covalent modification. Consequently effects such as risk of excessive bleeding, ulcer formation or foetal deformation limit the use of aspirin in dealing with long term diseases. Nowadays it is mainly considered as the important component in the treatment of cardiovascular conditions due to its anti-platelet activity 1,3. Other types of non-selective NSAIDs such as piroxicam, ibuprofen or diclofenac, constitute majority of therapeutic agents being prescribed however due to harmful effects they are being considered less effective in the long term treatment. The damage to the gastrointestinal (GI) system is due to inhibition of COX-1 expressed in GI mucosa which results in formation of ulcers with associated bleeding. Therefore since the main target for choosing those drugs is found to be of inflammatory nature (inhibition of COX-2) they are nowadays preferred in topical dosage forms 1,3,5. The consequence of the undesired effects caused by non-selective COX inhibitors targeted new approach towards development of more specifically acting agents. The era began on discovery of the second isoform of cyclooxygenase and introduction of first COX-2 selective agent (1999) was introduced to the market within 10 years since its discovery with celecoxib and rofecoxib for the treatment of arthritis. The discovery proposed mechanism of actions of both enzymes within the body with COX-1 possessing more constitutive effects especially in GI tract. It was therefore suggested that COX-2 was an inducible form in conditions such as inflammation and pain, symptoms desired in treatment of human diseases associated with the effects of COX-2 isozyme 1,3. 2. ASPIRIN THE ORIGINAL COX INHIBITOR (Joyce) 2.1. Pharmacology and chemistry of Aspirin Plant ingredient salicin was discovered in the willow bark and leaves in the 17th century by a greek physician (Hippocrates) who prescribed it as an analgesic and antipyretic. Further into the 17th century a crude form of salicylic acid was made by a German scientist (Charles Frederic von Gerhardt). This was followed by production of a purer form of salicylic acid by another German chemist (Karl Johann Kraut). Finally in 1897 a German chemist Felix Hoffmann, who worked for the pharmaceutical company Bayer, was assigned the task to find a better derivative of salicylic acid. He also had his own personal reasons for wanting to find a better derivative. His father had been taking salicylic acid for his arthritis pain but could no longer take it without vomiting3,7. In 1889 Hoff man then found a way of acetylating the hydroxyl group on the benzene ring of salicylic acid to form acetylsalicylic acid. Hoffman father tried the new derivative and it was pronounced effective. The name ‘ASPIRIN was given to the drug by Bayer chief pharmacologist Henrich Dreser7. Aspirin was found to have antipyretic, analgesic and anti-inflammatory effects. It does this by inhibiting cyclo-oxygenase(COX) or prostaglandin endoperoxide synthase(PGHS) enzyme irreversibly. COX is responsible for cyclizing arachidonic acid and adds the 15-hydroperoxy group to form PGG2 which is the precursor to prostaglandins. An enzyme perioxidase is responsible for reducing the hydroperoxy group of PGG2 to the hydroxyl group of PGH2.(4)(See Figure 15- prostaglandins synthesis) Prostaglandins can be described as chemical mediators that produce a variety of strong physiological effects in the body. Most importantly they are responsible for the activation of the inflammatory response, production of pain, and fever. There are three isoforms of the COX enzyme of which aspirin has an effect on two which are COX-1 and COX-2. Aspirin binds covalently modifiying COX-1 through acetylation of its Ser-530 and COX-2 through acetylation of its serine 516 residue by placing a bulky constituent (acetyl) and this directly inhibits binding of arachidonic acid. Aspirins action is more potent against COX-1 than against COX-2. This difference in inhibition of the two COX enzymes by aspirin is due to the larger volume of the COX-2 active site produced by the Val-523 substitution at the side pocket. (1,7, 9) The difference in the size of the active site has been exploited by pharmaceutical companies to develop selective COX-2 inhibitors (section 4) COX-1 is an essential enzyme expressed in majority of tissues and also in platelets. It is responsible for prostaglandin production involved in homeostatic mechanisms e.g. platelet aggregation, gastric wall protection, regulation of renal blood flow and initiation of labour in childbirth. In contrast, COX-2, is an inducible form which becomes up regulated by inflammatory mediators such as cytokine (Interleukin and tumour necrosis factor). 2.2 The problems associated with aspirin(1, 10) a. Unwanted effects GASTRIC PROBLEMS The inhibition of COX 1 can produce gastric disturbances as an unwanted effect because the prostaglandin production in the GI tract is a homeostatic mechanism to protect the gastric mucosa. It causes inherent symptoms like heartburn; dyspepsia, nausea, and abdominal pain. (1, 10)This effect can cause Aspirin users to change or discontinue its use. Some of these inherent symptoms are quite common for most NSAIDs. Secondly it can also causes gastro duodenal mucosal lesions such as erosions and asymptomatic ulcers, which may or may not heal spontaneously; and finally more serious gastro ulcers with life-threatening complications like perforation, symptomatic ulcers, and bleeding ulcers. Symptoms of this could be black, bloody, or tar like stools or vomiting/coughing up blood REYES SYNDROME Reyes syndrome is a collection of symptoms consisting of altered consciousness, convulsions, low blood glucose, and enlargement of the liver associated with fatty infiltration of the liver. It is a deadly disease, which can strike any child, teenager, or adult without warning. All body organs are normally affected, but the liver and brain are antagonised the most. In 1965 it was stipulated that Reyess syndrome can be caused by the administration of aspirin in children under 16years of age. There is no discovered mechanism for the role of salicylate in this but it is thought that aspirin enhances the release of tumour necrosis factor which induces apoptosis of cells which can cause inflammation, viral replication e.t.c. SALICYLISM This is caused by the excessive ingestion of aspirin. There are two main pathways in the metabolism of aspirin. (10)Phase 1 reaction that involves the oxidation of aspirin to salicylic acid by a cytochrome P450 monooxygenase. By addition of a reactive group (OH) to get it ready for conjugation to a soluble component and hence aid excretion. This conjugation involves the attachment of small polar molecules glycine and gluconoride to salicylic acid. This results in further deactivation of the aspirin and the production of water-soluble metabolites that will be readily excreted in the urine or bile. The pathway conjugated with glycine, is the one that is easily overloaded in cases of toxicity. Thus elimination of salicylic acid slows down and accumulation leads to a variety of side effects. Below are the pathways showing oxidation and conjugation. This excess salicylate produces toxic effects include below. Ringing in ears Hyperventilation which causes increase in CO2- respiratory alkalosis, Dehydration: increased water loss due to hyperventilation Loss of carbonic acid metabolic acidosis. This in turn will reduce the blood pH, and make aspirin return to its non-ionised form allowing free aspirin in the blood stream. Hyperthermia. These pathways overload uncouples the energy producing processes (oxidative phosphorylation) of the mitochondria thus causing production of heat rather than ATP. Fatality especially in children Interactions with other drugs Reduced effect of aspirin if given with ibuprofen and avoid concomitant use of aspirin with NSAIDS due to increased side effects. Increase risk of bleeding when aspirin is given with coumarins, SSRIs, clopidogrel, illoprost, and sibutramine, Aspirin enhances effect of Heparins, Phenytoin, Valporate, Aspirin antagonises effect of Spirolactone, Sulfinpyrazone and Probenacid Rate of excretion of aspirin is increases by some antacids. The effect of aspirin on the gastrointestinal tract may be enhanced by the intake of alcohol and corticosteroids. 3. NON STEROIDAL ANTINFLAMMATORY DRUGS NON SELECTIVE COX INHIBITORS (Christina) 3.1 Isozymes of Cyclooxygenase Cyclooxygenase has various isozymes. The main isozymes are COX-1 and COX-2, however there is now evidence of a third form- COX-3. COX, originally known as prostaglandin H synthase is responsible for the oxidation of arachadonic acid to prostaglandin G2 and prostaglandin H2. It catalyses the reaction in which the arachadonic acid substrate and two molecules of O2 are converted to prostaglandin G2 and then in the perioxidase reaction Prostaglandin G2 is reduced to PGH2 by a 2 electron reduction. The COX isozymes are heme containing enzymes that are homodimers. Each monomer contains three main domains; A membrane binding domain, a N-terminal epidermal growth factor domain and a C-terminal catalytic domain. COX-1 is made up of 602 amino acids while COX-2 is comprised of 604.3 The catalytic reaction in COX takes place in a hydrophobic channel in the core of the enzyme while the peroxidise reaction takes place in the heme containing region near the surface of the enzyme. The membrane binding domain consists of four alpha helices with one helix that fuses with the catalytic domain. These helices congregate around an opening and through these openings fatty acids and NSAIDS are considered to enter the active site. The COX-1 isozyme is considered a constitutive enzyme. It is present in high volumes in most cells and tissues i.e. renal collecting tubules, monocytes, endothelium etc. However COX-2 is hardly noticeable in most cells, it is an inducible enzyme so it becomes more abundant in cells or tissues when macrophages are activated or by any other inflammation mediators e.g. TNF-a (tumor necrosis factor-alpha) or IL-1 (interleukin-1).5 Both COX-1 and COX-2 isozymes are attatched to the endoplasmic reticulum and nuclear envelope. The COX isozymes need to be N-linked glycosylated to enable them to be folded and attatched to the endoplasmic reticulum and nuclear envelope. The COX isozymes have very similar structures for their binding site, catalytic mechanisms and produce the same biosynthetic products3 COX-3 COX-3 a third isozyme was discovered in 2002 by Simmons and co-workers. They conducted a study on dogs and this resulted in them discovering a novel COX-1 splice variant termed COX-3 that was sensitive to acetaminophen (paracetamol). It was suspected for a while that acetaminophen worked by inhibiting a different specific isozyme due to the fact that it did not directly inhibit COX-1 and COX-2 very effectively at therapeutic concentrations but it generated prostanoids in neuronal systems. 3, 15 The Simmons and co-worker group showed that acetaminophen was the actual target for COX-3, and that it acted separately from COX-1 and COX-2. 3 Canine COX-3 is a membrane bound protein consisting of 613 amino acids with a molecular weight of ~65 kDa. It has a high expression in cells and tissues like COX-1 suggesting it may be a constitutive enzyme. However the question that needs to be asked is if generalisations can truly be made on the presence of COX-3 in humans based on Canine studies, so future experiments need to be designed to clarify whether a human COX-3 actually does exist that acts independently from COX-1 and COX-2 in vivo. 14 NSAIDs are known to inhibit COX in order for them to exhibit their anti-inflammatory actions, a structural NSAID binding study was carried out. The COX-1 active site contains a long hydrophobic channel that extends from the membrane binding domain to the core of the COX monomer. The tip of the COX active site houses Tyr385 that is located near the heme iron. Ser530 is positioned just below Tyr385 and that is the site for aspirin acetylation. Glu524 and Arg120 are positioned at the mouth of the COX-1 channel. A typical NSAID such as fluobriprofen, when introduced to the COX enzyme, its carboxylate moiety is usually directed towards the mouth of the COX-1 channel in order for it to be positioned in the most ideal place that will allow it to interact with the two polar residues Glu524 and Arg120. From these studies a better insight into the binding profiles of NSAIDs were observed. Non selective NSAIDs can bind in three different ways: Reversibly (e.g. Ibuprofen) Fast, low affinity reversible binding followed by a higher affinity, time dependant slowly reversible binding (e.g. fluobriprofen) Rapid, reversible binding followed by a covalent modification of the enzyme (e.g. Aspirin) 3 Arg120, Glu524, Tyr355 and His90 form a network of hydrogen bonds at the entrance of the COX channel acting like a gate to the binding site. NSAIDs generally bind between the upper portion of the COX channel near Tyr 385 and Arg 120 which is at the mouth of the COX channel. 3 Through the use of hydrogen bonding and electrostatic interactions, the carboxyl moiety of acidic NSAIDs like fluoribiprofen interact with Arg120 in both COX isozymes. The significant differences in the structure of the binding sites for both COX isozymes has been manipulated to enable the design of selective COX-2 inhibitors. In the COX-2 active site there is an extra accessible pocket due to the presence of a smaller valine amino acid residue at position 523 and a valine substitution at position 434, unlike COX-1, this difference increases the overall volume at the COX-2 active site by about 20%. 1 This means that due to reduced steric and ionic crowding at the mouth of the channel by Arg120, non acidic selective COX-2 inhibitors can show an enhanced and specific binding to the COX-2 enzyme. Another structural difference exists at the amino acid residue 513 where COX-1 has a histidine residue and COX-2 has an arginine moiety. 1 These small differences provides flexibility in the substrates that can be utilised in the COX-2 active site. 3.2 Problems Associated With Non Selective Non Steroidal Anti-Inflammatory Drugs NSAIDs are one group of drugs that are regularly used by the worlds population to relieve pain, reduce inflammation and lower temperature. They are COX inhibitors and act to inhibit the catalysation of arachadonic acid to PGH2. COX-1 is constitutively present in most cells while COX-2 is induced by chemical mediators of inflammation and activated macrophages.13 COX-1 and COX-2 as mentioned above have 2 specific roles. The 1st role gives PGG2 and the other role is in the peroxidise reaction that gives PGH2. Both COX-1 and COX-2 inhibitors work by inhibiting the 1st and main role i.e. inhibiting the conversion of arachadonic acid to PGG2. COX-1 and COX-2 possesses hydrophobic channels within their core. The classical NSAIDs exhibit their effects by blocking these enzymes halfway down the COX channel near Tyr385 and the Arg120 which is at the mouth of the COX channel by hydrogen bonding to the Arg120 residue. This results in the prohibition of any fatty acid substrates from entering the catalytic domain of the COX enzyme.3 In COX-1, these drugs tend to inhibit the enzyme quickly yet generally the inhibition is often reversible, however in COX-2 the inhibition is time dependant and often results in irreversible inhibition. As mentioned before, the COX-1 and COX-2 isozyme differ slightly. In the COX-2 active site there is an extra accessible side pocket due to the presence of a smaller valine amino acid residue at position 523 instead of isoleucin as in COX-1. This is important for understanding why some NSAIDs are selective for the COX-2 isozyme.13 There are a number of side effects associated with traditional NSAID therapy. NSAIDs can cause renal failure, liver damage/disorders, aseptic meningitis, skin reactions and bone marrow disturbances which can interfere with bone fracture healing. However amongst them all gastrointestinal (GI) toxicities is amongst the most common. These are believed to arise from the inhibition of COX-1 in the gastric mucosa.14 GI toxicities In humans and other species it has been shown that COX-1 not COX-2 is constitutively expressed throughout the GI tract.13 COX-1 is responsible for the synthesis of prostaglandins like PGE2 and PGI2 which are responsible for protecting the GI mucosa by reducing acid secretion in the stomach by the parietal cells, increasing blood flow in the mucosa and stimulating the release of viscous mucous. This leads to conditions of ulcers, dyspepsia, diarrhoea, nausea and vomiting and can even lead to gastric bleeding in some cases. These undesirable side effects have led to the development of COX-2 selective inhibitors. These drugs are effective anti-inflammatorys and reflect good analgesic effects. They have considerable less gastric damage due to the fact they selectively inhibit COX-2 with minimal action on COX-1. Unfortunately the use of COX-2 selective drugs has been associated with increased incidence of myocardial infarction and stroke.3 Renal effects Prostaglandins especially PGE2 and PGI2 are involved in regulating renal blood flow and vascular tone. Recent studies have shown that COX-2 is constitutively expressed in the macula densa, epithelia cells lining the ascending loop of henle and medullary interstitial cells of the renal papillae, while COX-1 is constitutively expressed in the collecting ducts, loop of henle and in the vasculature. The COX-2 enzyme is associated with normal renal function and inhibition of COX-2 results in NSAID-induced sodium retention while inhibition of COX-1 results in a disease in glomerular filtration rate.3 This conclusively tells us that both COX-1 and COX-2 are involved in the physiology of the kidneys. However therapeutic doses in patients with normal renal function are at little risk of renal complications. It is mostly neonates and the elderly who are more susceptible as well as patients with heart, liver or kidney disease. 4. SELECTIVE COX 2 INHIBITORS (Nadine) 4.1 Reasoning behind selective inhibition 4.2 Benefits and risks 5. MECHANISM OF ACTION OF COX INHIBITORS IN HUMAN DISEASES 5.1 Analgesic (Joyce) Pain can be defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Pain is a self protection mechanism which helps of forces us to identify danger and move away from it. It is one of the main symptoms used to identify a condition in medicine. Removing pain is very essential in terms of either eliminating the disease or condition or in fact suppressing its effect. This can be done by the use of medicines called analgesics. Pain receptors also called nociceptors are present on special nerve fibres that are sensitive to noxious of harmless stimuli. The stimulation of these receptors are on A-delta and C-fibers which are located in skin, connective tissue, viscera, muscle e.t.c. COX inhibitors act by blocking transmission to peripheral nerves. Pain associated with I. Arthritis Arthritis is the inflammation of joints. The inflammation and movement of the joints cause extreme pain in the sufferer. There are two major types a. Osteoarthritis(10) This is a chronic disease that features the breakdown of the joints cartilage. Cartilage is flexible connective tissue found in between joints that cushions or protects the ends of the bones and allows easy mobility of joints. This breakdown of cartilage causes the bones to rub against each other creating friction, causing joint tension, pain and loss of mobility in the joint. There are different types of arthritis of which osteoarthritis is most common; it can also be referred to a degenerative joint disease. There are two types of osteoarthritis, primary of which is associated with old age, general wear and tear of the cartilage. And secondary where it occurs where there is a cause example obesity, trauma, or hereditary. Treatment: Paracetamol may be considered as first line therapy for Osteoarthritis patients with mild to moderate pain. If the pain does not respond to paracetamol or patient has severe symptoms then other traditional NSAIDs like Ibuprofen, diclofenac or coxibs should be used. Coxibs have shown to produce reduced GI side effects. However they have the probability of increasing cardiovascular risk because they inhibit prostacyclin production in endothelial cells but not thromboxane in platelets, hence this can increase the chance of a thrombus formation. The choice of a coxib or a specific NSAID should be based on the patient characteristics and risk factors. b. Rheumatoid arthritis(12 ) This is an autoimmune disease of unknown origin whose major characteristic is the inflammation and erosion of the synovial membrane or synovium. This membrane lines and surrounds the joint and synovial cavity. The synovium secretes a slightly viscous, clear fluid known as synovial fluid, which lubricates cavity that lies between the cartilage and joint on the bone. In Rheumatoid arthritis accumulation of the synovial fluid builds up within the joint space and causes inflammation. This makes the joint look and feel swollen. Rubor occurs do to the increased blood flow to the area because of inflammation. In conditions of long-term RA, joint degeneration can occur causing mobility to be very painful and restricted. Treatment: Aspirin used to be used to treat RA but because of its GI toxicity. The use of aspirin as first line of therapy has been superceded by other NSAIDs. There are a large number of NSAIDs that have been invented since aspirin, but have similarities in toxicities e.g. Ibuprofen, naproxen meloxicam, etodolac selective COX-2 inhibitors have been invented to control inflammation. These drugs were designed to combat the gastrointestinal risk of NSAIDS, but there are concerns of increases in cardiovascular risk. II. Cancer (11) Can be defined as an abnormal growth of cells as when a group ofcellsdisplayuncontrolled division,invasion, and sometimesmetastasis. Cells become cancer cells because of its damaging effect to the DNA of the cell. A normal cell will try to repair damaged DNA but in a cancer cell it replicates with the damaged DNA. The cancer cell continues making new cells that the body does not require. The most common cause of cancer pain is infiltration of the tumour into bone. Bone metastases occur as a consequence of different types of cancer. Another mechanism of pain apart from bone metastasis is the secretion of Prostaglandins by carcinomas. For this reason, NSAIDs should be included in any regimen to control pain associated with bone metastasis. Because NSAIDs do not activate opioid receptors, they can provide additional pain relief when combined with an opioid analgesic. Thus, combining an NSAID with an opioid analgesic may provide adequate pain control with a clinically significant reduction in opioid dose. This opioid-sparing effect of NSAID therapy allows the clinician to diminish the side effects associated with opioid therapy without sacrificing pain control. Coxibs: Another Option for Cancer Pain Management(11) The recent introduction of the coxibs, on their use in cancer patients is still being studied. Oncologists are replacing NSAIDs, with the use of coxib, because of the improved safety profile compared to traditional agents. Surgical oncologists are exploring the use of coxibs both preoperatively and during the post-operative period to reduce opioid usage in order to speed the recovery process 5.2 Anti-pyretic (Nadine) 5.3 Anti-inflammatory (Christina) To date there are over 100 inflammatory diseases- each of which causes the degeneration of connective tissue in one or more parts of the body. These include: Rheumatoid Arthritis Osteoarthritis Atherosclerosis Irritable Bowel Disease Alzheimers and many more. Inflammation is characterised by dolor, rubor, calor and tubor, its one of the bodys ways of responding to harmful stimuli, pathogens, injury or disease. These usually initiate an acute or chronic inflammatory response. Arthritis is a general term used to characterise inflammation in the joints. Rheumatoid arthritis describes arthritis that occurs on both sides of the body i.e symmetrical. These usually occur in the wrists, hands and knees. It is not known what causes this disease many theories have been put forward but it happens when the immune system begins to attack the joints. A number of anti-inflammatory drugs are available worldwide and are widely used to relieve pain, swelling and inflammation associated with soft tissue inflammation. A number of these drugs act via the inhibition of COX. When you experience pain and inflammation from arthritis, an increase in microvascular permeability occurs selectively in post-capillary venules. The endothelial cells undergo conformational change leading to vascular leakage through gaps between the adjacent endothelial cells. At the site of injury phagocytes are attracted and move into the affected tissue along with plasma. The plasma causes the associated swelling observed in inflammation and the phagocytes engulf dead cells and bacteria. Prostanoic acids are